2. Signaling Pathways
  3. CRTH2 (GPR44)

CRTH2 (GPR44) (Th2细胞趋化因子受体同源分子)

DP2 receptor; Prostaglandin DP2 receptor

Th2 细胞的趋化受体同源分子 (CRTH2) 已被证实能介导嗜酸性粒细胞、嗜碱性粒细胞和 Th2 型 T 淋巴细胞的趋化作用。肥大细胞的主要产物前列腺素 (PG) D(2) 被认为是 CRTH2 的主要配体。

CRTH2 是检测健康和疾病状态下循环人类 2 型 Th 和 2 型 T 细胞毒性细胞的最可靠标记。已知嗜酸性粒细胞、嗜碱性粒细胞、T 辅助细胞 2、巨噬细胞和中性粒细胞上表达的 CRTh2 受体参与这些细胞的趋化作用和激活，这些细胞是引发过敏性疾病炎症反应的关键事件。

Chemoattractant receptor homologous molecule of Th2 cells (CRTH2) has been shown to mediate the chemotaxis of eosinophils, basophils and Th2-type T lymphocytes. The major mast cell product prostaglandin (PG) D(2) is considered to be the principal ligand of CRTH2.

CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. CRTh2 receptors, expressed on eosinophils, basophils, T-helper 2 cells, macrophages, and neutrophils are known to be involved in chemotaxis and activation of these cells, which form the key events initiating the inflammatory response in allergic diseases.

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